gg_wald: closed-form Wald tests for genome-wide analysis of gene-gene interactions


gg_wald is a C++ program that conducts Wald tests for testing gene-gene interactions.


Benefits of gg_wald:

o   Feasible for genome-wide interaction analysis. It runs as fast as other computationally efficient tests of gene-gene interactions

o   Flexible parameterization. It can conduct both 4-degree-of-freedom and 1-degree-of-freedom tests. Tests with other parameterization, such as dominant or recessive interaction effects, can be obtained by slightly modifying the source code

o   Statistically valid. The results are based upon Wald tests, which are asymptotically equivalent to likelihood ratio tests.


C++ source code


The manuscript, supporting text: S1, S2